Studies of Tubercle Bacillus-histiocyte Relationships* Vii. Homologous and Heterologous Transi~er of Cellular Resistance
نویسنده
چکیده
A form of cellular resistance which has been intensively investigated in our laboratories is one that is directed against Mycobacterium tuberculosis. This cellular resistance, which is readily demonstrated with the histiocytes of rabbits immunized with the BCG strain of tubercle bacillus, is expressed in a number of ways depending upon the conditions of experimentation; one expression of this resistance is refractoriness of immune histiocytes to the necrotizing action of virulent bacilli (1).
منابع مشابه
Studies of Tubercle Bacillus-histiocyte Relationships
Immunization of mice or guinea pigs with BCG rendered all or most of the histiocytes of these animals resistant to necrotization by virulent H37Rv; this cellular resistance was mediated by immune serum. Immune mouse histiocytes (from BCG-immunized animals) were able to induce cellular resistance in normal homologous and heterologous (rabbit) animal species; mouse histiocytic ribosomes were also...
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Studies of passive transfer of cellular resistance, as manifested by refractoriness to necrotization with virulent tubercle bacilli, have shown that immune histiocytes or immune lymphocytes were effective transferring agents; immune polymorphonuclear leucocytes and immune serum as well as comparable cells from normal animals lacked this capacity. Comparisons of immune histiocytes and immune lym...
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Studies of acquired immunity have revolved around the relative importance of humoral and cellular factors. As previously indicated (1), valid conclusions concerning the role of cells in acquired immunity against tuberculosis require analyses of bacterium-cell relationships during periods when the in dtro cell populations show no change in cell numbers. Under such conditions, it was observed tha...
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متن کاملLysosomal Acid Hydrolases in Mice Infected with Bcg* by Kazuhisa
Infection of laboratory animMs with BCG, an attenuated strain of tubercle bacilli, results in functional changes of the RES x, especially enhanced activity. The heightened phagocytic capacity may well contribute toward resistance of such animals to homologous and heterologous virulent infection (2). One of the consequences of altered activity of the RES induced by infection with BCG is the well...
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تاریخ انتشار 2003